| 摘要 |
The invention relates to a method for treatment of restenosis and other vascular proliferative disorders, using an adenoviral vector encoding a cytotoxic or cytostatic molecule, along with a cell-preserving molecule in a host cell, thereby allowing persistent transgene expression in the host. The method further relates to adenoviral vectors and/or transgene products useful for the treatment of restenosis. In a preferred embodiment, the vectors comprise the gene encoding a Fas ligand, and a gene which modulates the apoptotic effects of said Fas ligand, such as p35. |
