| 发明名称 |
HUMANIZED ANTI-CCR2 ANTIBODIES AND METHODS OF USE THEREFOR |
| 摘要 |
The present invention relates to a humanized antibody or functional fragment thereof which binds to a mammalian (e.g., human) CC-chemokine receptor (2) (CCR2) or a portion of the receptor and blocks binding of a ligand to the receptor. The invention further relates to a method of inhibiting the interaction of a cell bearing mammalian CCR2 with a ligand thereof, and to u se of the antibodies and fragments in therapeutic, prophylactic and diagnostic methods.
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| 申请公布号 |
CA2399080(A1) |
申请公布日期 |
2001.08.09 |
| 申请号 |
CA20012399080 |
申请日期 |
2001.02.02 |
| 申请人 |
MILLENNIUM PHARMACEUTICALS, INC. |
发明人 |
JONES, S. TARRAN;O'BRIEN, SIOBHAN;NEWMAN, WALTER;LAROSA, GREGORY J.;HORVATH, CHRISTOPHER;O'KEEFE, THERESA |
| 分类号 |
C12N15/09;A61K38/00;A61K39/395;A61P9/00;A61P9/10;A61P19/02;A61P25/00;A61P29/00;A61P31/18;A61P37/06;A61P43/00;C07K14/715;C07K16/28;C07K16/46;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N15/13;C12P21/02;(IPC1-7):C12N15/62;C12N15/63 |
主分类号 |
C12N15/09 |
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