| 摘要 |
<p>A method of identifying compounds which stimulates or inhibits apoptosis by contacting the cell expressing a gene with the compound of interest and determining the ability of the compound to stimulate or inhibit apoptosis is provided. In addition a method and its pharmaceutical composition to treat degenerative disease, auto-immune disease and tumors in a subject by administering to the subject a compound which stimulates a gene in the Fas pathway is disclosed. The use of casein kinase inhibitor, dicumarol, sulfinpyrazone, Nrf-2 inhibitor or a glutathione precursor as a medicament is also disclosed. A method of identifying genes that encode for inhibitors of cell death by inactivating genes in cells by sensitizing cells to cell death, using gene inactivators, applying positive selection to the sensitized cells and using subtraction analysis to identify the genes that have been inactivated is also provided.</p> |
