PROCESS FOR PRODUCING DIALYTIC AMYLOID FIBER POLYMERIZATION NUCLEI, METHOD OF SCREENING REMEDIES FOR DIALYTIC AMYLOIDOSIS AND REMEDIES FOR DIALYTIC AMYLOIDOSIS

摘要

A process for producing dialytic amyloid fiber polymerization nuclei which comprises reacting dialytic amyloid fiber polymerization nuclei with recombinant beta 2-microglobulin to thereby effect passage fragmentation; a method of screening remedies for dialytic amyloidosis by inhibiting the amyloid fiber extending reaction with the use of the above-described polymerization nuclei; and remedies for dialytic amyloidosis such as glycosaminoglycan, fucoidan, sulfated diazo-colorant compounds, etc. which are obtained with the use of the above-described screening method.