摘要 |
The present invention provides methods for assessing cardiovascular status in an individual, which comprise determining the sequence at one or more polymorphic positions within the human genes encoding ACE, AT1, AGT, renin, aldosterone synthase, type-2 angiotensin II receptor, endothelin receptor, and beta -adrenoceptor. The invention also provides isolated nucleic acids encoding polymorphisms in genes encoding ACE, AT1, AGT, renin, aldosterone synthase, type-2 angiotensin II receptor, endothelin receptor and beta -adrenoceptor, nucleic acid probes that hybridized to polymorphic positions, kits for the prediction of cardiovascular status, and nucleic acid and peptide targets for use in identifying candidate cardiovascular drugs. |
申请人 |
EURONA MEDICAL AB |
发明人 |
NORBERG, LEIF, TORBJORN;ANDERSSON, MARIA, KRISTINA;LINDSTROM, PER, HARRY, RUTGER;JONSSON, LENA |