| 发明名称 |
Constrained helical peptides and methods of making same |
| 摘要 |
Provided are cyclized peptides with a constrained region(s) having an alpha-helical conformation. Constrained helical peptides having amino acid sequences from HIV gp41 are provided, as is their use in preparing antibodies that prevent viral membrane fusion. Also provided are methods for making such cyclized peptides.
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| 申请公布号 |
US6271198(B1) |
申请公布日期 |
2001.08.07 |
| 申请号 |
US19970965056 |
申请日期 |
1997.11.05 |
| 申请人 |
GENENTECH, INC. |
发明人 |
BRAISTED ANDREW C.;JUDICE J. KEVIN;MCDOWELL ROBERT S.;PHELAN J. CHRISTOPHER;STAROVASNIK MELISSA A.;WELLS JAMES A. |
| 分类号 |
A61K38/00;A61K39/00;C07K14/16;(IPC1-7):A61K38/00 |
主分类号 |
A61K38/00 |
| 代理机构 |
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| 主权项 |
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