NOVEL POLYPEPTIDES VraS AND VraR

摘要

Polypeptides represented by SEQ ID NO:3 (VraS) and SEQ ID NO:4 (VraR); polynucleotides (vraS and vraR) respectively encoding these polypeptides; antagonists of these polypeptides; and a detection method with the use of the above polynucleotides. Vancomycin-sensitivity can be restored by using the above antagonists of VraS and VraR. Thus, VraS and VraR are usable as remedies for infection with vancomycin-tolerant MRSA. By using vraR and vraS which are newly found, a vancomycin-tolerant strain can be identified.