发明名称 Coated implants
摘要 <p>An implant, usually a stent, has a coating of a cross-linked water swellable polymer matrix preferably having a dry thickness of at least 0.1 mum, and a pharmaceutically active compound, the polymer having pendant cationic and pendant zwitterionic groups. The active is usually an anionic compound such as a nucleic acid. The polymer is peferably formed from 2-methacyloy-loxyethyl-2'-trimethylammoniumethyl phosphate inner salt, trialkylammoniumalkyl(meth)acrylate and a cross-linkable monomer such as omega-(trialkoxysilyl)alkyl(meth)acrylate, optionally with a termonomer such as a higher alkyl (meth)acrylate. The stent is coated with polymer, cross-linked then contacted with a solution or dispersion of active compound in a solvent which swells the polymer whereby the active is absorbed into the polymer matrix. The stent is delivered by usual means into a body lumen and the actives released over an extended period of time into the wall of the lumen and/or fluid flowing therein.</p>
申请公布号 AU2865301(A) 申请公布日期 2001.07.31
申请号 AU20010028653 申请日期 2001.01.24
申请人 BIOCOMPATIBLES LIMITED 发明人 GERALD LAURENCE HUGHES;TERRENCE ALBERT VICK;JIN HAI WANG
分类号 A61L27/00;A61F2/84;A61L27/34;A61L27/54;A61L31/04;A61L31/10;A61L31/16 主分类号 A61L27/00
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