Use of paramyxovirus vector in gene transfer into blood vessel

摘要

Use of a recombinant Paramyxovirus vector has enabled transferring nucleic acid into the blood vessel at high efficiency by short exposure. The present invention provides a Paramyxovirus vector used for transferring nucleic acid into the vascular cells and a method for transferring nucleic acid using such vector. Pretreatment of blood vessels with protease significantly improved the efficiency of transfection into the medial layer. The expression of transfected genes was stable in the vascular cells for a long period. The method of the present invention enables efficiently transferring genes into tissues such as the blood vessel lumen, media, and adventitia in short time in such applications as gene therapy.