METHOD FOR PRODUCING QUINOLYLPROPENAL

摘要

PROBLEM TO BE SOLVED: To provide a method for producing 3-[2-cyclopropyl-4-(4-fluorophenyl)-3- quinolyl]prop-2-enal in high yield from a quinolylacrylonitrile derivative by a simple means. SOLUTION: This method comprises the following process: 3-[2- cyclopropyl-4-(4-fluorophenyl)-3-quinolyl]prop-2-ene nitrite is reduced by Raney nickel in the presence of a formic acid amine salt and an organic acid.