| 摘要 |
Certain novel N-hydroxyurea compounds having the ability to inhibit the 5- lipoxygenase enzyme and having formula (I) and the pharmaceutically acceptab le salts thereof, wherein A is C1-C4 alkylene, CH(R), CH(R)CH2 or CH(R)CH2CH2, in which R is methyl or ethyl; m and n are each zero or one; R1 and R2 are each hydrogen, C1-C4 alkyl or C2-C6 alkenyl; X is O or S; Y is O, S, CH=CH or CC; Ar1 is phenyl or phenyl mono-substituted with halogen, C1-C4 alkyl, C1-C4 alkoxy, C1-C4 halo-substituted alkyl or C1-C4 halo-substituted alkoxy; and A r2 is phenylene, pyridylene or phenylene mono- or di-substituted with halogen, C1- C4 alkyl, C1-C4 alkoxy, C1-C4 halo-substituted alkyl or C1-C4 halo-substitut ed alkoxy. These compounds are useful in the treatment or alleviation of inflammatory diseases, allergy and cardiovascular diseases in mammals and as the active ingredient in pharmaceutical compositions for treating such conditions.
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