发明名称 D-proline derivatives
摘要 New compounds have the formula:wherein R, R1, X and Y have the meanings described herein. Methods are set forth for synthesizing these compounds and using these compounds to treat diseases associated with amyloidosis, such as Alzheimer's disease, maturity onset diabetes mellitus, familial amyloid polyneuropathy, scrapie, and Kreuzfeld-Jacob disease.
申请公布号 US6262089(B1) 申请公布日期 2001.07.17
申请号 US20000505375 申请日期 2000.02.16
申请人 HOFFMAN-LA ROCHE INC. 发明人 HERTEL CORNELIA;HOFFMANN TORSTEN;JAKOB-ROETNE ROLAND;NORCROSS ROGER DAVID
分类号 C07K5/078;A61K31/00;A61K31/40;A61K31/401;A61K31/4015;A61K38/08;A61P3/00;A61P3/10;A61P9/04;A61P9/10;A61P25/00;A61P25/28;A61P43/00;C07D207/16;C07D207/22;C07D207/277;C07D401/14;C07D403/06;C07D403/12;C07D403/14;C07D405/14;C07D409/14;C07D413/14;C07D417/14;C07D419/14;C07D521/00;(IPC1-7):A61K31/401;A61K31/443;C07D295/10;C07D410/14 主分类号 C07K5/078
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