PROCESS FOR PRODUCING NATURAL SUBSTANCE-DERIVED COMPOUND LIBRARY

摘要

PURPOSE: A method for preparing a natural substance-derived compound library is provided to use the compound purified by means of solid-phase to develop new medicines and/or pharmaceutically functional materials such as anticancer drugs. CONSTITUTION: The method for preparing the chemical library comprises a solid-phase synthesis manner comprising of adhering anchor compound of base material to a solid phase resin; blocking the obtained material to exclude specific functional groups such as alcohol, phenol, carbonyl, amine radicals of extract from natural substances; attaching the resultant extract to the solid phase resin bonded with the anchor compound to react together; washing and removing un-attached residual compounds and/or reactants; and cutting the bonded anchor compound from the solid phase resin. The obtained chemical library is useful for detecting or optimizing any physiological active materials including enzyme inhibitors or acceptors.