Production of optically active 2-substituted tetrahydropyran-4-ones

摘要

Optically active 2-substituted tetrahydropyran-4-ols or esters thereof may be prepared using esterases or hydrolases from the corresponding racemic mixtures of esters or alcohols. This provides a route to the corresponding optically active ketones.The racemic mixtures are preferably in the cis-form. such mixtures may be produced by-reacting but-3-ene-1-ol with an aldehyde in the presence of an acid.