发明名称 New composition, used in in vitro or ex vivo cellular transfection, comprises a nucleic acid and a mineral particle with an exchangeable layer structure
摘要 A composition (I) comprising at least one nucleic acid (NA) of /> 1000 base pairs and a mineral particle (Ia) with an exchangeable layer structure, is new. Independent claims are also included for the following: (1) a composition (II) comprising at least a NA and (Ia) with the formula: (MII1-xMIIIx(OH2))x+(Xx/mm-.nH2O)x- where MII is magnesium, MIII is aluminum, Xm- is an interlamellar carbonate, and m is an integer /- 1, x is 0-1, and n is /> 0; (2) preparing (I) and (II); and in vitro or ex vivo transferring (M1) NAs into cells, comprising: (a) forming (I) or (II); and (b) contacting the cells with (I) or (II).
申请公布号 FR2803206(A1) 申请公布日期 2001.07.06
申请号 FR19990016707 申请日期 1999.12.30
申请人 AVENTIS PHARMA S.A. 发明人 PITARD BRUNO
分类号 A61K9/00;A61K9/14;A61K9/16;A61K9/51;A61K47/02;C12N15/87;(IPC1-7):A61K47/02;A61K48/00 主分类号 A61K9/00
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