NAPHTHOQUINONE DERIVATIVES AND THEIR USE IN THE TREATMENT AND CONTROL OF TUBERCULOSIS

摘要

Naphthoquinone derivatives of Formula (1): wherein, R represents an OH group, methyl ether, ethyl ether or a similar ether; R1 represents a methyl, ethyl or similar aliphatic hydrocarbon derivative; R2 and R3 each independently represent hydrogen or a group selected from: (A), (B), or (C) wherein R5 represents an OH group, methyl ether, ethyl ether or a similar ether and R6 represents a methyl, ethyl or similar aliphatic hydrocarbon derivative; R4 represents hydrogen or a group selected from: (D), (E) or (F) wherein R7 represents an OH group, methyl ether, ethyl ether or a similar ether and R8 represents a methyl, ethyl or similar aliphatic hydrocarbon derivative; or pharmaceutically acceptable salts thereof, are useful for the treatment and/or control of a tuberculosis in a patient caused by Mycobacterium tuberculosis.