发明名称 |
COMPLEXES FOR TRANSPORTING NUCLEIC ACID INTO EUKARYOTIC HIGHER-CELLS |
摘要 |
Complexes of nucleic acid and polyethyleneimine (PEI), wherein PEI is modified with a hydrophilic polymer covalently coupled thereto, such as polyethyleneglycol, and processes for preparing them. A cellular ligand such as transferrin is optionally coupled to PEI. The complexes may be used for preparing pharmaceutical compositions for transferring therapeutically effective genes into mammalian cells.
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申请公布号 |
US2001005717(A1) |
申请公布日期 |
2001.06.28 |
申请号 |
US20000446317 |
申请日期 |
2000.04.17 |
申请人 |
WAGNER ERNST;OGRIS MANFRED;KIRCHEIS RALF;BRUNNER SYLVIA |
发明人 |
WAGNER ERNST;OGRIS MANFRED;KIRCHEIS RALF;BRUNNER SYLVIA |
分类号 |
C12N15/09;A61K31/711;A61K38/00;A61K39/00;A61K47/48;A61K48/00;A61M36/14;C08G73/04;C08G81/00;C12N15/87;(IPC1-7):A61M36/14;A61K51/00;A61K31/70;A61K9/14 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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