INTERACTIONS OF KU POLYPEPTIDES

摘要

Ku is a protein found in a wide range of organisms. It comprises two tightly-associated subunits termed Ku70 and Ku80. The present invention relates to the discovery and characterisation of an interaction between Ku70 and Ku80 and DNA-PKcs. Various applications based on this interaction are provided. These are relevant to numerous cellular processes which are of interest in therapeutic contexts.