发明名称 |
PNA SKELETON TELOMERE RECOGNITION PROBE AND METHOD FOR DETERMINING TELOMERE LENGTH |
摘要 |
PROBLEM TO BE SOLVED: To quickly and accurately determine the length of a telomere using a small amount of DNA so as to easily assess the extent of skin aging. SOLUTION: The subject method comprises determining the length of a telomere by electrophoretic separation of a telomere DNA obtained from cells and detecting the telomere DNA using a PNA skeleton telomere recognition probe; wherein the probe to be used is such as to have a PNA skeleton, have a base sequence of N-terminal-(CCCTAA)n-C-terminal or N-terminal-(TTAGGG)n- C-terminal (n is 3-5) and be labeled with a radioisotope, fluorescent compound, chemiluminescent compound or enzyme. |
申请公布号 |
JP2001161364(A) |
申请公布日期 |
2001.06.19 |
申请号 |
JP19990345539 |
申请日期 |
1999.12.03 |
申请人 |
SONY CP LABORATORIES INC;MIWA NOBUHIKO |
发明人 |
YAMASHITA RITSURO;AMAN YOSHIKAZU;SUGIMOTO YOSHIO;MIWA NOBUHIKO |
分类号 |
C12N15/09;C12Q1/68;G01N33/50;G01N33/566 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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