发明名称 |
Antisense oligonucleotide compositions targeted to angiotensin converting enzyme MRNA and methods of use |
摘要 |
Antisense oligonucleotides specific for mammalian ACE mRNA have been identified. Administration of these oligonucleotides to animals resulted in a decrease in blood pressure, but no significant change in heart rate. Methods for discovering other oligonucleotides with the same activity are taught, as are uses of the antisense molecules for treatment of human and animal diseases.
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申请公布号 |
US6248724(B1) |
申请公布日期 |
2001.06.19 |
申请号 |
US19980162484 |
申请日期 |
1998.09.25 |
申请人 |
UNIVERSITY OF FLORIDA |
发明人 |
MOORE MARK D.;PHILLIPS M. IAN;MOHUCZY DAGMARA |
分类号 |
A61K38/00;C12N15/113;(IPC1-7):A61K31/70;A01N43/04;C07H21/04;C12Q1/68;C12N5/00 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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