Beta-3 adrenoceptor agonists

摘要

The following compounds: 3'-[[2R-[[2-(3-chlorophenyl)-2R-hydroxyethyl]amino]propyl]amino]-[1,1'-biphenyl]-3-carboxylic acid; 6-[3-[[2R-[[2-(3-chlorophenyl)-2R-hydroxyethyl]amino]propyl]amino]phenyl]-2-pyridinecarboxylic acid; (R)-3-[3-[[2-(3-chlorophenyl)-2-hydroxyethyl]amino]ethyl]amino]phenyl]-4-pyridinecarboxylic acid; 3-[3-[[2R-[[2-(3-chlorophenyl)-2R-hydroxyethyl]amino]propyl]amino]phenyl]-4-pyridinecarboxylic acid; (R)-3-[3-[[2-(3-chlorophenyl)-2-hydroxyethyl]amino]ethyl]amino]phenyl]-2-pyridinecarboxylic acid; 3-[3-[[2R-[[2-(3-chlorophenyl)-2R-hydroxyethyl]amino]proyl]amino]phenyl]-2-pyridinecarboxylic acid; and pharmaceutically acceptable derivatives thereof are disclosed. These compounds are useful as agonist for human beta-3 adrenoceptor.