摘要 |
PURPOSE: New maleic acid derivatives as a ceramide type compound having a characteristic similar to natural ceramide and a process for the preparation thereof are provided, which can be used as materials for improving dry skin by increasing a moisture maintaining function and accelerating the change of a horny layer. CONSTITUTION: Aliphatic organic acid derivatives of formula 3 bonded with alkylamide are dissolved in an organic solvent, reacted with amine derivatives of the formula; R1-NH-R2 in the presence of a weak alkali, washed with acidic and basic aqueous solutions and recrystallized after distillation under reduced pressure to produce the title compound of formula 1. In formula, R1 is H or C2-4 alkyl containing 1 to 2 hydroxyl groups, R2 is C4-24 alkyl having a saturated or unsaturated aliphatic chain and R3 is C8 to 22 alkyl having a saturated or unsaturated aliphatic chain.
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