Crystalline 3-hydroxylactone-containing products can be prepared in high yield and purity in a one-pot process by treating the corresponding 3,5-dihydroxy acid with a strong mineral acid in a cold, aprotic, water-miscible solvent to effect lactonization, followed by addition of excess acid to effect crystallization of the lactonized product from the reaction mixture.
申请公布号
WO0130773(A3)
申请公布日期
2001.06.14
申请号
WO2000US29220
申请日期
2000.10.23
申请人
MERCK & CO., INC.;MCMANUS, JAMES;ANOUSIS, NICHOLAS;GENUS, JOHN;HANCOCK, CHRISTOPHER
发明人
MCMANUS, JAMES;ANOUSIS, NICHOLAS;GENUS, JOHN;HANCOCK, CHRISTOPHER