发明名称 |
METHOD FOR THE STEREOSELECTIVE SYNTHESIS OF CYCLIC AMINO ACIDS |
摘要 |
The instant invention is a route to stereospecific 3-substituted 5-membered ring isomers of Formula (A). The final products are useful as agents in the treatment of epilepsy, faintness attacks, hypokinesia, cranial disorders, neurodegenerative disorders, depression, anxiety, panic, pain, neuropathological disorders, gastrointestinal disorders such as irritable bowel syndrome (IBS), inflammation especially arthritis, sleep disorders, premenstrual syndrome, and hot flashes. The invention provides novel routes to synthesize stereoselectively analogs of gabapentin (Neurontin3) of Formulas (I), (II), (III) and (IV) wherein R is C1-C10 alkyl or C3-C10 cycloalkyl and pharmaceutically acceptable salts thereof.
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申请公布号 |
WO0142190(A1) |
申请公布日期 |
2001.06.14 |
申请号 |
WO2000US32570 |
申请日期 |
2000.11.30 |
申请人 |
WARNER-LAMBERT COMPANY;BRYANS, JUSTIN, STEPHEN;BLAKEMORE, DAVID, CLIVE;WILLIAMS, SOPHIE, CAROLINE |
发明人 |
BRYANS, JUSTIN, STEPHEN;BLAKEMORE, DAVID, CLIVE;WILLIAMS, SOPHIE, CAROLINE |
分类号 |
C07C227/20;C07B53/00;C07B57/00;C07B61/00;C07C51/08;C07C51/347;C07C51/353;C07C51/377;C07C51/41;C07C51/43;C07C53/134;C07C57/46;C07C69/608;C07C69/616;C07C227/32;C07C227/34;C07C229/28;C07C255/31;C07C255/41;C07C265/08;C07C271/12;(IPC1-7):C07C227/32 |
主分类号 |
C07C227/20 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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