Pentapeptide hydrochloride, processes of its preparation and intermediates therefor

摘要

In the present invention, there is described pentapeptide hydrochloride of the formula Mei2Val-Val-MeVal-Pro-Pro-NHBz1.HCl, which is present in crystalline form. It is prepared from the compound of the formula Z-Val-Val-MeVal-Pro-ORe1, in which Z represents a benzyloxycarbonyl protecting group, which might be optionally substituted on the phenyl ring and Re1 represents alkyl containing 1 to 5 carbon atoms. In the present invention, there are also described intermediates for preparing the above indicated pentapeptide hydrochloride. The above-described compound exhibits antineoplastic activity.