| 摘要 |
The present invention provides means and methods for the detection of a disease or pathological condition associated with molecular misreading of coding sequences in the genome and/or associated with the secretion of aberrant protein, comprising providing a sample of a body fluid and/or tissue of a patient and determining a level of a proteins aberrant counterpart in said body fluid and/or tissue. Molecular misreading seems to be a general cause for the synthesis of nonsense transcripts. Previously, molecular misreading was deemed to occur in age related disease and was seen as one of the mechanisms causing age related disease. In the present invention we observed that molecular misreading also occurs in healthy individuals. Surprisingly, the levels of aberrant protein in the body fluids of healthy non demented individuals is higher than in individuals suffering from age related disease. Determining levels of aberrant proteins, such as a +1 protein, allows diagnosing Alzheimers disease in an early stage of this disease, when mild cognitive impairments are apparent in these patients, and allows detecting the effects of any treatment on the disease process. |
