Receptor that binds anti-convulsant compounds

摘要

The claimed invention is substantially purified rat forebrain receptor, wherein said receptor:a) binds Compound A with a Kd of 40 nM and a Bmax of 220 pmol/g;b) binds Compound B with a Kd of 2 nM and a Bmax of 220 pmol/g protein; andc) has a molecular weight of about 130 kD.Compounds A and B are known anti-convulsant compounds, such that this receptor will be useful in screening for compounds that have therapeutic activity for the treatment of CNS-related disorders.