发明名称 Dissolution of triprolidine hydrochloride
摘要 The present invention is directed to pharmaceutical compositions containing triprolidine and an ionic additive that improves the measured availability of the triprolidine in the tablet, as indicated by standard USP assay for triprolidine in pharmaceutical compositions. The invention also provides a process for producing compositions having improved triprolidine availability and a process for improving the performance of a pharmaceutical composition in a dissolution assay measuring triprolidine availability. The ionic additive can be, for example, an alkali metal salt, such as sodium chloride or potassium chloride.
申请公布号 US6245785(B1) 申请公布日期 2001.06.12
申请号 US19980201250 申请日期 1998.11.30
申请人 WARNER LAMBERT COMPANY 发明人 CRUZ VICTOR A.;NICHOLS W. MICHAEL;SORG ALBERT F.;TORTAROLO GEORGE E.;BESS WILLIAM;KULKARNI NEEMA
分类号 A61K9/20;A61K47/02;A61P37/08;(IPC1-7):A61K31/44 主分类号 A61K9/20
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