摘要 |
A compound of formula (I) and pharmaceutically acceptable salts, solvates and hydrolysable esters thereof wherein; X<1> represents O or S; R<1> and R<2> independently represent H, halogen, -CH3 and -OCH3; n represents 1 or 2; X2 represents NH, NCH3 or O; One of Y and Z is N, and the other is O or S; R<3> represents phenyl or pyridyl (wherein the N is in position 2 or 3) and is optionally substituted by one or more halogen, NO2, NH2, CF3, OCF3, OC1-6 straight or branched alkyl, C1-6 straight or branched alkyl, alkenyl or alkynyl with the provision that when R<3> is pyridyl, the N is unsubstituted; R<4> represents CF3 or CH3.
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