摘要 |
The present invention provides a solid preparation comprising a crystal of [ 3- [(2R)-[[(2R)-(3-chlorophenyl)-2-hydroxyethyl]amino]propyl]-1H-indol-7- yloxy]acetic acid (Compound A), especially a crystal of Compound A having a particle size of not larger than 100 .mu.m at the cumulative weight distribution value of 50 %, and not larger than 200 .mu.m at the cumulative weight distribution value of 95 %, preferably a solid preparation having the excellent stability and the content uniformity of Compound A, which is prepared by preparing granules of the crystal of Compound A with fillers, disintegrants and binders, and then followed by mixing said granules with external excipients.
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申请人 |
DAINIPPON PHARMACEUTICAL CO., LTD. |
发明人 |
FUJITA, MEGUMI;KURIYAMA, TERUAKI;IWATA, MOTOKAZU;ODAI, OSAMU;KAWASHIMA, HITOSHI;FUJII, AKIHITO;HARADA, HIROSHI;FUJIWARA, KEIICHI;KATO, SHIRO |