发明名称 |
ANTIPICORNAVIRAL COMPOUNDS AND COMPOSITIONS, THEIR PHARMACEUTICAL USES, AND MATERIALS FOR THEIR SYNTHESIS |
摘要 |
Compounds of formula (I), where the formula variables are as defined herein, are disclosed that advantageously inhibit or block the biological activity o f the picornaviral 3C protease. Also disclosed are compounds of formula (II) where the formula variables are as defined herein that advantageously inhibi t or block the biological activity of the picornaviral 3C protease. These compounds, as well as pharmaceutical compositions containing these compounds , are useful for treating patients or hosts infected with one or more picornaviruses, such as rhinovirus 3C proteases. Intermediates and synthetic methods for preparing such compounds are also described.
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申请公布号 |
CA2392504(A1) |
申请公布日期 |
2001.06.07 |
申请号 |
CA20002392504 |
申请日期 |
2000.12.01 |
申请人 |
AGOURON PHARMACEUTICALS, INC. |
发明人 |
JOHNSON, THEODORE O., JR.;PRINS, THOMAS J.;ZHOU, RU;DRAGOVICH, PETER S. |
分类号 |
A61K31/437;A61K31/44;A61K31/4412;A61K31/4427;A61K31/443;A61K31/4433;A61K31/4436;A61K31/4439;A61K31/444;A61P31/12;A61P31/14;A61P31/16;A61P43/00;C07D;C07D213/75;C07D401/12;C07D405/12;C07D405/14;C07D409/12;C07D413/12;C07D413/14;C07D471/04;(IPC1-7):C07D213/75 |
主分类号 |
A61K31/437 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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