发明名称 Novel topoisomerase poisons for the treatment of proliferative disorders
摘要 Methods for the treatment of a proliferative disorder are provided in which a subject in need of such treatment is administered an effective amount of a compound selected from: compounds of formula (I) or a pharmaceutically acceptable salt thereof, wherein X<1> and X<2> are independently H, Cl, F, Br, I, CN, CF3 or NO2, and Ar<1> is a substituted or unsubstituted aryl or a substituted or unsubstituted heteroaryl; and compounds of formula (II) wherein X<3> and X<4> are each independently H, Cl, F, Br, I, CN, CF3 or NO2; Y is (C2-C6)alkylene or (C2-C6)heteroalkylene; and Z is Cl, F, Br, I, CN, CF3 or NO2.
申请公布号 AU1592301(A) 申请公布日期 2001.06.06
申请号 AU20010015923 申请日期 2000.11.10
申请人 FRED HUTCHINSON CANCER RESEARCH CENTER 发明人 JOHN R. LAMB;JULIAN SIMON;HEATHER DUNSTAN;STEPHEN H. FRIEND
分类号 A61K31/16;A61K31/50;C07C251/86;C07D237/14 主分类号 A61K31/16
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