OXIDIZED APOLIPOPROTEINS AND METHODS OF USE

摘要

The present invention relates to oxidized forms of apolipoproteins and methods of use in diagnosis and treatment of diseases associated with oxidative stress, such as cardiovascular diseases, in particular of atherosclerosis. Specifically, oxidized forms of ApoA-1 and ApoA-II having specific methionine residues oxidized are provided. Methods of use include increasing effux and alpha -TOH, lowering lipid concentrations and preventing or treating lipid-associated conditions are provided. Methods of detecting oxidative stress, genotypes and extent of lipid associated conditions are also provided by utilizing the oxidative apolipoproteins.