MELANOCORTIN-4 RECEPTOR DEFICIENT CELLS, NON-HUMAN TRANSGENIC ANIMALS AND METHODS OF SELECTING COMPOUNDS WHICH REGULATE BODY WEIGHT

摘要

Cells and non-human transgenic animals have been engineered to be deficient in the gene encoding the melcanocortin-4 receptor protein (MC-4R). These MC-4R deficient transgenic animals can be used to select for and test potential modulators of MC-4R. This data allows for methods of screening for preferential MC-4R modulators which effect body weight through modulation of both metabolic rate and food intake, as well as associated methods of treati ng various disorders associated with inappropriate regulation of body weight.