TREATING CANCER BY INCREASING INTRACELLULAR MALONYL COA LEVELS

摘要

A method of killing cancer cells by acute elevation of cellular malonyl Coenzyme A (Malonyl CoA) which leads to apoptosis. Elevation of malonyl CoA may be induced by inhibition of fatty acid synthase (FAS), or by other manipulation of fatty acid metabolism. Alternatively, growth of tumor cells may be inhibited by FAS inhibition in conjunction with inhibition of carniti ne palmitoyltransferase-1 (CPT-1). Combination therapy with drug(s) that inhibi t fatty acid synthesis by inhibiting acetyl CoA carboxylase (the first enzyme in the fatty acid synthesis pathway) and drug(s) that inhibit CPT-1 e.g. etomox ir may be expected to induce apopptosis in tumor cells.