SYNTHESIS OF 2'-DEOXY-L-NUCLEOSIDES

摘要

This invention provides processes for the preparation of compounds having structure (A) wherein X and Y are same or different, and H, OH, OR, SH, SR, NH2, NHR', or NR'R"; Z is H, F, Cl, Br, I, CN or NH2. R is hydrogen, halogen, lower alkyl of C1-C6 or aralkyl, NO2, NH2, NHR', NR'R", OH, OR, SH, SR, CN, CONH2, CSNH2, CO2H, CO2R', CH2CO2H, CH2CO2R', CH=CHR, CH2CH=CHR, or C=CR. R' and R" are same or different, and lower alkyl of C1-C6. R<13> is hydrogen, alkyl, acyl, phosphate (monophosphate, diphosphate, triphosphate, or stabilized phosphate) or silyl.