发明名称 |
COMPOSITIONS AND METHODS FOR REGULATING ENDOGENOUS INHIBITOROF ATP SYNTHASE, INCLUDING TREATMENT FOR DIABETES |
摘要 |
The present invention provides compositions and methods for altering mitochondrial ATP production, including binding and functional assays exploiting IF1 interactions with ATP synthase. Also disclosed are methods fo r screening assays for a compound capable of reducing mitochondrial ATP hydrolysis and/or increasing mitochondrial ATP synthesis, including pharmaceutical compositions identified by such methods. The invention also provides methods for treating diabetes, and in particular, type 2 DM, using an agent identified according to the disclosed methods.
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申请公布号 |
CA2390646(A1) |
申请公布日期 |
2001.05.17 |
申请号 |
CA20002390646 |
申请日期 |
2000.11.10 |
申请人 |
MITOKOR |
发明人 |
ANDERSON, CHRISTEN M.;CLEVENGER, WILLIAM |
分类号 |
G01N33/50;A61K45/00;A61P3/10;C07K19/00;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N15/09;C12N15/62;C12P21/02;C12Q1/34;C12Q1/48;G01N33/15;G01N33/573;(IPC1-7):C12Q1/34;C12N15/87 |
主分类号 |
G01N33/50 |
代理机构 |
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主权项 |
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地址 |
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