发明名称 |
PEPTIDE ANALOGS AND MIMETICS SUITABLE FOR IN VIVO USE IN THE TREATMENT OF DISEASES ASSOCIATED WITH ABNORMAL PROTEIN FOLDING INTO AMYLOID, AMYLOID-LIKE DEPOSITS OR beta -SHEET RICH PATHOLOGICAL PRECURSOR THEREOF |
摘要 |
The present invention is an inhibitory peptide capable of inhibiting beta pleated sheet formation in amyloid beta -peptide. The inhibitory peptide is a beta sheet breaker peptide analog designed by chemical modification of beta sheet breaker peptide capable of inhibiting beta pleated sheet formation in amyloid beta -peptide. The present invention also includes an inhibitory peptide capable of inhibiting conformational changes in prion PrP protein associated with amyloidosis. The inhibitory peptide being a beta sheet breaker peptide analog designed by chemical modification of a beta sheet breaker peptide capable of inhibiting the conformational changes in prior PrP protein associated with amyloidosis. In addition, the present invention includes a peptide mimetic with the structure PMiA beta 5. In another embodiment, the peptide mimetic has the structure PMiPrP13. In yet another embodiment, the peptide mimetic has the structure PMiPrP5.
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申请公布号 |
WO0134631(A2) |
申请公布日期 |
2001.05.17 |
申请号 |
WO2000US30416 |
申请日期 |
2000.11.04 |
申请人 |
AXONYX, INC. |
发明人 |
SOTO-JARA, CLAUDIO |
分类号 |
A61K38/00;A61K31/20;A61P25/28;C07C229/28;C07C229/34;C07K5/02;C07K7/06;C07K7/08;C07K7/64;C07K14/47;(IPC1-7):C07K/ |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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