Arylacylaminoethanes, process of their preparation and pharmaceutical preparation in which they are comprised

摘要

In the present invention there are described arylacylaminoethanes of the general formula I, in which Ri1 represents aryl or heteroaryl, Ri2 represents hydrogen, a lower alkyl or aryl-lower alkyl, Ri3 represents hydrogen, a lower alkyl, aryl or heteroaryl, Ri4 represents aryl or heteroaryl, X represents alkylene containing 1 to 7 carbon atoms, Ci2-Ci7-alkenylene having 2 to 7 carbon atoms and Am represents an optionally substituted amino group, and their salts. These compounds are active as NK1 antagonists. In the present invention there are further described a process for preparing these compounds as well as pharmaceutical preparation in which they are comprised.