| 摘要 |
A method and apparatus for lowering the body temperature of a patient while reducing shivering by using a heat exchange device in combination with an anti-shivering mechanism that temporarily reduces shivering. The devices disclosed include a catheter having a heat exchange balloon thereon with heat exchange fluid circulating through the interior of the balloon. The heat exchange balloon is placed in the vasculature of a patient, and heat exchange fluid at a temperature other than the temperature of the blood in the vasculature is circulated through the interior of the balloon to add or remove heat from the blood of the patient. Various anti-shivering agents are disclosed including dopamine receptor blockers, dopamine receptor agonists, kappa opioid receptor agonists, opioid agonist-antagonist analgesics, seratonin 5 HT1a agonists, and pharmaceutically acceptable salts of any members of this group. Specific examples of each are give. A control system for the control of the patient's temperature is disclosed for controlling the patient's temperature in conjunction with administering the anti-shivering mechanism.
|
