| 摘要 |
A method is provided for detecting a cell proliferation disorder in an individual which is based on the spatial distribution of specific components , such as proteins and other molecules, in a mammalian cell nucleus allowing o ne to establish whether a cell is in its normal state or has undergone transformation to a tumorogenous state. If transformation has occurred, such spatial distribution allows detection and grading of the tumor. The method comprises: a) determining the spatial distribution of at least one specific component in the cell nucleus of a sample from said individual to be analyze d; b) comparing said spatial distribution with the spatial distribution of the same at least one specific component in a reference sample; and c) characterizing said at least one specific component of said sample to be analyzed based upon comparison with said same at least one component in said reference sample. The method is useful in diagnostics as an efficient method for the (early) detection, and monitoring treatment, of proliferation disorders, in particular carcinomas, especially in humans.
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