发明名称 7-[(4'-TRIFLUOROMETHYL-BIPHENYL-2-CARBONYL)AMINO]-QUINOLINE-3-CARBOXYLIC ACID AMIDES, AND METHODS OF INHIBITING THE SECRETION OF APOLIPOPROTEIN B
摘要 This Invention relates to compounds of Fomula I (see formula I) that inhibit the secretion of apolipoprotein B, to pharmaceutical compositio ns comprising the compounds, and to methods of treating and/or preventing atherosclerosis, obesity, diabetes, hyperlipidemia, hyperliproproteinemia, hypercholesterolemia, hypertriglyceridemia, hypoalphalipoproteinemia, pancreatitis, myocardial infarction, stroke, restenosis, or Syndrome X. This invention als o relates to methods of reducing the secretion of apolipoprotein B and/or inhibiting microsomal triglyceride transfer protein.
申请公布号 CA2325358(A1) 申请公布日期 2001.05.10
申请号 CA20002325358 申请日期 2000.11.08
申请人 PFIZER PRODUCTS INC. 发明人 BERTINATO, PETER;HAMANAKA, ERNEST SEIICHI;RUGGERI, ROGER BENJAMIN;WILSON, DOUGLAS PAUL
分类号 A61K31/47;A61K31/4709;A61K45/00;A61P1/18;A61P3/04;A61P3/06;A61P3/10;A61P9/00;A61P9/10;A61P43/00;C07D215/54;C07D401/12;C07D401/14;C07D405/12;C07D405/14;C07D409/12;(IPC1-7):C07D215/54;C07D411/00;C07D413/00;C07D417/00;C07D473/00;C07D475/00;C07D455/02;C07D471/04;C07D409/14;A61K31/470;A61K31/495;A61K31/53;A61K31/535;A61K31/537;A61K31/54 主分类号 A61K31/47
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