INHIBITORS OF THE INOSITOL POLYPHOSPHATE 5-PHOSPHATASE SHIP2 MOLECULE

摘要

The present invention is related to an inhibitor of the inositol polyphospha te 5-phosphatase SHIP2 protein or its encoding nucleotide sequence identified b y SEQ ID NO. 1 or of SHIP2 mRNA expression. The present invention is also related to a pharmaceutical composition comprising said inhibitor and an adequate pharmaceutically acceptable carrier or diluent and to a non-human knock-out mammal comprising homozygously or heterozygously a partial or tota l deletion in its genome of the inositol polyphoshate 5-phosphatase SHIP2 nucleotide sequence.