METHOD FOR THE FORMULATION OF SUBSTANCES HAVING A LOW WATER-SOLUBILITY AND LIPOPHILICITY AND FORMULATION THUS OBTAINED

摘要

The present invention relates to a method for encapsulating substances, in particular drugs, that have a low water-solubility and lipophilicity, which method comprises providing a lipid system comprising one or more negatively charged lipid(s); combining the lipid system with the substance(s) in a medi um at a low total solutes concentration; subjecting the mixture thus obtained t o one or more cycles of freezing and thawing to produce lipid-coated aggregate s of the substance(s), and optionally removing the free (non-enclosed) substance(s). The method is in particular suitable for encapsulating cisplat in.