Ligand chelated paramagnetic mri contrast agents

摘要

Compounds and methods for imaging by MRI tissues having predetermined cellular receptors are described. The imaging agents comprise a receptor-binding ligand covalently bound to a paramagnetic chelate, optionally in combination with compound for enhancing cellular uptake of said agent. Improved MRI is achieved by acquiring MRI signals after period of time sufficient to achieve receptor mediated cellular concentration of the imaging agent.