A method of screening compounds to identify those compounds which inhibit the Asp 1 mediated cleavage of a polypeptide or protein substrate, the method comprising: providing a reaction system comprising Asp 1 and substrate; and measuring the extent of cleavage of the substrate in the presence of test compound as compared with the extent of cleavage in the absence of test compound, and compounds identified thereby as well as compounds which are inhibitors of Asp 1 modulated APP cleavage and their use in therapy including the treatment or prophylaxis of beta amyloid protein-related disease including AD.
申请公布号
WO0131054(A1)
申请公布日期
2001.05.03
申请号
WO2000GB04028
申请日期
2000.10.19
申请人
SMITHKLINE BEECHAM P.L.C.;SMITHKLINE BEECHAM CORPORATION;CHRISTIE, GARY;HUSSAIN, ISHRUT;POWELL, DAVID, JONATHAN
发明人
CHRISTIE, GARY;HUSSAIN, ISHRUT;POWELL, DAVID, JONATHAN