发明名称 NOVEL COMPOUNDS
摘要 <p>An antibody, or a derivate or a fragment thereof, having a binding structure for a target structure is described. The antibody is displayed in, and on the cell surface of, human gastrointestinal epithelial tumour cells and in a subpopulation of normal human gastrointestinal epithelial cells. Said binding structure comprises the complementarity determining region (CDR) sequences in the light chain comprising essentially the amino acids number 23-33 (CDR1), 49-55 (CDR2), 88-98 (CDR3) of the amino acid sequence shown in SEQ ID NO:2, and the CDR sequences in the heavy chain comprising essentially the amino acids number 158-162 (CDR1), 177-193 (CDR2), 226-238 (CDR3) of the amino acid sequence shown in SEQ ID NO:2, or other binding structures with similar unique binding properties. There is also described a target structure displayed in, or on the surface of tumour cells, vaccine compositions, pharmaceutical compositions as well as methods related to human malignant diseases.</p>
申请公布号 WO0130854(A2) 申请公布日期 2001.05.03
申请号 WO2000SE02082 申请日期 2000.10.26
申请人 ACTIVE BIOTECH AB;BRODIN, THOMAS, N.;KARLSTROEM, PIA, J.;OHLSSON, LENNART, G.;TORDSSON, M., JESPER;KEARNEY, PHILLIP, P.;NILSON, BO, H., K. 发明人 BRODIN, THOMAS, N.;KARLSTROEM, PIA, J.;OHLSSON, LENNART, G.;TORDSSON, M., JESPER;KEARNEY, PHILLIP, P.;NILSON, BO, H., K.
分类号 C12N15/09;A61K38/00;A61K39/395;A61P35/00;A61P35/04;A61P37/02;C07K14/705;C07K16/18;C07K16/28;C07K16/30;G01N33/53;G01N33/574;(IPC1-7):C07K16/30;A61K39/00 主分类号 C12N15/09
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