Novel nucleotide sequences coding for the poxB gene.

摘要

Isolated polynucleotide (I) comprises: (a) a sequence that is at least 70% identical to a sequence that encodes a polypeptide comprising the fully defined 579 amino acid sequence (S2) given in the specification; (b) encodes a protein at least 70% identical with (S2); (c) a sequence complementary to (a) or (b); or (d) a sequence comprising at least 15 consecutive bases from (a), (b) or (c). Independent claims are also included for the following: (1) a vector comprising (I); (2) coryneform bacteria, functioning as host cell, that include a deletion or insertion in the poxB gene; and (3) production (M) of L-amino acids, especially L-lysine, by fermenting bacteria in which the poxB gene is at least partly suppressed.