Method and apparatus for monitoring solid phase chemical reactions

摘要

A method for monitoring a solid phase chemical reaction comprises the steps of: (a) providing a reaction mixture comprising a solid support and a reaction medium, (b) contacting an attenuated total reflection element to said reaction mixture; and then (c) monitoring the chemical reaction on the solid support through the attenuated total reflection element. The monitoring step is carried out by attenuated total reflection spectroscopy. An advantage of the invention is that the chemical reaction on the solid support may be directly monitored, rather than indirectly monitoring that chemical reaction by monitoring reaction constituents in the reaction medium.