4,5-disubstituted-2-aminopyrimidines

摘要

Pyrimidines of formla (1) are described: wherein R¹ is a -XR₆ group; R² and R³ which may be the same or different is each a hydrogen or halogen atom or a group selected from an optionally substituted aliphatic, cycloaliphatic, heteroaliphatic, heterocycloaliphatic, -OH, -OR¹⁰ [where R¹⁰ is an optionally substituted aliphatic, cycloaliphatic, heteroaliphatic, heterocycloaliphatic, aromatic or heteroaromatic group) -SH, -NO₂, -CN, -SR¹⁰, -COR¹⁰, S(O)R¹⁰, -SO₂R⁸, -SO₂N(R⁸)(R⁹), -CO₂R⁸, -CON(R⁸)(R⁹), -CSN(R⁸)(R⁹), -NH₂ or substituted amino group; R⁴ is a X¹R¹¹ group where X¹ is a covalent bond or a -C(R¹²)(R¹³)- [where each of R¹² and R¹³ is a hydrogen or halogen atom or a hydroxyl, alkyl or haloalkyl group] or -C(O)- group and R¹¹ is an optionally substituted phenyl, thienyl, thiazolyl or indolyl group; R⁵ is a halogen atom or an alkynyl group; and the salts, solvates, hydrates and N-oxides thereof. The compounds are selective KDR kinase and/or FGFr kinase inhibitors and are of use in the prophylaxis and treatment of disease states associated with angiogenesis